Ventilator-induced lung injury induces a positive signalling feedback loop between Nrf2 and amphiregulin

Aims and objectives: Mechanical ventilation (MV) is a life saving intervention, but also bears the risk of ventilator-induced lung injury (VILI) with pulmonary inflammation. The mechanisms underlying VILI are not yet fully understood. This study was designed to examine a possible interaction of the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2), a major regulator of the cellular antioxidant defence system, with the...