A Novel Type of Non-coding RNA, nc886, Implicated in Tumor Sensing and Suppression

Volume: 13, Issue: 2, Pages: 26 - 26
Published: Jan 1, 2015
Abstract
nc886 (=vtRNA2-1, pre-miR-886, or CBL3) is a newly identified non-coding RNA (ncRNA) that represses the activity of protein kinase R (PKR). nc886 is transcribed by RNA polymerase III (Pol III) and is intriguingly the first case of a Pol III gene whose expression is silenced by CpG DNA hypermethylation in several types of cancer. PKR is a sensor protein that recognizes evading viruses and induces apoptosis to eliminate infected cells. Like viral...
Paper Details
Title
A Novel Type of Non-coding RNA, nc886, Implicated in Tumor Sensing and Suppression
Published Date
Jan 1, 2015
Volume
13
Issue
2
Pages
26 - 26
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