Age-Dependent Pleiotropy Between General Cognitive Function and Major Psychiatric Disorders

BackgroundGeneral cognitive function predicts psychiatric illness across the life course. This study examines the role of pleiotropy in explaining the link between cognitive function and psychiatric disorder.MethodsWe used two large genome-wide association study data sets on cognitive function—one from older age, n = 53,949, and one from childhood, n = 12,441. We also used genome-wide association study data on educational attainment, n = 95,427,...