Current prostate biopsy interpretation: criteria for cancer, atypical small acinar proliferation, high-grade prostatic intraepithelial neoplasia, and use of immunostains.

Context.—The past decade has brought major changes in prostate biopsy sampling, interpretation, and reporting. Objective.—To summarize current information on diagnostic decision making, Gleason grading, “atypical” diagnoses, and use of immunostaining. Data Sources.—Pertinent literature from 1985 to 2005 is reviewed, emphasizing recent findings. Conclusions.—Diagnosis begins by evaluating a focus of atypical single-cell layer lined acini...