Why Does Infection With Some Helminths Cause Cancer?

Paul J. Brindley; José Manuel Correia da Costa; Banchob Sripa

doi:https://doi.org/10.1016/j.trecan.2015.08.011

doi.org/10.1016/j.trecan.2015.08.011

Why Does Infection With Some Helminths Cause Cancer?

Paul J. Brindley

56

,

José Manuel Correia da Costa

21

,

Banchob Sripa

49

Trends in Cancer18.40

Volume: 1, Issue: 3, Pages: 174 - 182

Published: Nov 1, 2015

Abstract

Infections with Opisthorchis viverrini, Clonorchis sinensis and Schistosoma haematobium are classified as Group 1 biological carcinogens: definitive causes of cancer. These worms are metazoan eukaryotes, unlike the other Group 1 carcinogens including human papilloma virus, hepatitis C virus, and Helicobacter pylori. By contrast, infections with phylogenetic relatives of these helminths, also trematodes of the phylum Platyhelminthes and major...