Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
Abstract
Inflammatory caspases (caspase-1, -4, -5 and -11) are critical for innate defences. Caspase-1 is activated by ligands of various canonical inflammasomes, and caspase-4, -5 and -11 directly recognize bacterial lipopolysaccharide, both of which trigger pyroptosis. Despite the crucial role in immunity and endotoxic shock, the mechanism for pyroptosis induction by inflammatory caspases is unknown. Here we identify gasdermin D (Gsdmd) by genome-wide...
Paper Details
Title
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
Published Date
Sep 16, 2015
Journal
Volume
526
Issue
7575
Pages
660 - 665
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