Changes in Structural-Mechanical Properties and Degradability of Collagen during Aging-associated Modifications.

Volume: 290, Issue: 38, Pages: 23291 - 23306
Published: Sep 18, 2015
Abstract
During aging, changes occur in the collagen network that contribute to various pathological phenotypes in the skeletal, vascular, and pulmonary systems. The aim of this study was to investigate the consequences of age-related modifications on the mechanical stability and in vitro proteolytic degradation of type I collagen. Analyzing mouse tail and bovine bone collagen, we found that collagen at both fibril and fiber levels varies in rigidity and...
Paper Details
Title
Changes in Structural-Mechanical Properties and Degradability of Collagen during Aging-associated Modifications.
Published Date
Sep 18, 2015
Volume
290
Issue
38
Pages
23291 - 23306
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