A Phase III trial to investigate the timing of radiotherapy for prostate cancer with high‐risk features: background and rationale of the Radiotherapy – Adjuvant Versus Early Salvage (RAVES) trial

Objectives To test the hypothesis that observation with early salvage radiotherapy ( SRT ) is not inferior to ‘standard’ treatment with adjuvant RT ( ART ) with respect to biochemical failure in patients with pT3 disease and/or positive surgical margins ( SMs ) after radical prostatectomy ( RP ). To compare the following secondary endpoints between the two arms: patient‐reported outcomes, adverse events, biochemical failure‐free survival,...