Development and validation of an LC–MS/MS method for the determination of SB-505124 in rat plasma: Application to pharmacokinetic study

Volume: 117, Pages: 205 - 209
Published: Jan 1, 2016
Abstract
A sensitive, selective and rapid liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-MS/MS) method has been developed for the quantification of the novel transforming growth factor-β (TGF-β) inhibitor SB-505124 in rat plasma and then validated. Plasma samples were prepared by simple protein precipitation. Separation was performed on a Diamonsil ODS chromatography column using a mobile phase of acetonitrile and 0.1% (v/v)...
Paper Details
Title
Development and validation of an LC–MS/MS method for the determination of SB-505124 in rat plasma: Application to pharmacokinetic study
Published Date
Jan 1, 2016
Volume
117
Pages
205 - 209
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