The RNA-binding protein HuR/ELAVL1 regulates IFN-β mRNA abundance and the type I IFN response
Abstract
Secretion of type I interferon (IFN) is the first cellular reaction to invading pathogens. Despite the protective function of these cytokines, an excessive response to their action can contribute to serious pathologies, such as autoimmune diseases. Transcripts of most cytokines contain adenylate‐uridylate (A/U)‐rich elements (AREs) that make them highly unstable. RNA‐binding proteins (RBPs) are mediators of the regulatory mechanisms that...
Paper Details
Title
The RNA-binding protein HuR/ELAVL1 regulates IFN-β mRNA abundance and the type I IFN response
Published Date
Mar 12, 2015
Volume
45
Issue
5
Pages
1500 - 1511
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