Role of N‐cadherin in the regulation of hematopoietic stem cells in the bone marrow niche

Cell–cell and cell–extracellular matrix interactions between hematopoietic stem cells (HSCs) and their niches are critical for the maintenance of stem cell properties. Here, it is demonstrated that a cell adhesion molecule, N‐cadherin, is expressed in hematopoietic stem/progenitor cells (HSPCs) and plays a critical role in the regulation of HSPC engraftment. Furthermore, overexpression of N‐cadherin in HSCs promoted quiescence and preserved HSC...