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doi.org/10.1016/j.cell.2014.09.050

Integrated Genomic Characterization of Papillary Thyroid Carcinoma

..., Roger Kramer
11
Cell64.50
Volume: 159, Issue: 3, Pages: 676 - 690
Published: Oct 1, 2014
Abstract
Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Here, we describe the genomic landscape of 496 PTCs. We observed a low frequency of somatic alterations (relative to other carcinomas) and extended the set of known PTC driver alterations to include EIF1AX, PPM1D, and CHEK2 and diverse gene fusions. These discoveries reduced the fraction of PTC cases with unknown oncogenic driver from 25% to 3.5%. Combined analyses of...
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Paper Details
Title
Integrated Genomic Characterization of Papillary Thyroid Carcinoma
DOI
doi.org/10.1016/j.cell.2014.09.050
Published Date
Oct 1, 2014
Journal
Cell
Volume
159
Issue
3
Pages
676 - 690
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