Role of the leucine-rich repeat (LRR) domain of cryopyrin/NALP3 in monosodium urate crystal-induced inflammation

Objective The mechanism by which monosodium urate monohydrate (MSU) crystals intracellularly activate the cryopyrin inflammasome is unknown. The aim of this study was to use a mouse molecular genetics–based approach to test whether the leucine‐rich repeat (LRR) domain of cryopyrin is required for MSU crystal–induced inflammation. Methods Cryopyrin‐knockout lacZ (Cryo −Z/−Z ) mice and mice with the cryopyrin LRR domain deleted and fused to the...