HIF3α: the little we know

Hypoxia‐inducible factors ( HIF s) are key regulators of the transcriptional response to hypoxic stress. Three inducible isoforms of HIF are present in mammals. HIF 1α and HIF 2α are the best characterized and structurally similar isoforms, while HIF 3α is the most distantly related and is less studied. The HIF 3α gene undergoes complex regulation and produces a large number of long and short mRNA splice variants, which are translated into...