ADAMTS3 activity is mandatory for embryonic lymphangiogenesis and regulates placental angiogenesis
Abstract
The only documented activity of a subclass of ADAMTS proteases comprising ADAMTS2, 3 and 14 is the cleavage of the aminopropeptide of fibrillar procollagens. A limited number of in vitro studies suggested that ADAMTS3 is mainly responsible for procollagen II processing in cartilage. Here, we created an ADAMTS3 knockout mouse (Adamts3(-/-)) model to determine in vivo the actual functions of ADAMTS3. Heterozygous Adamts3(+/-) mice were viable and...
Paper Details
Title
ADAMTS3 activity is mandatory for embryonic lymphangiogenesis and regulates placental angiogenesis
Published Date
Oct 7, 2015
Journal
Volume
19
Issue
1
Pages
53 - 65
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