Targeting the Checkpoint to Kill Cancer Cells
Abstract
Cancer treatments such as radiotherapy and most of the chemotherapies act by damaging DNA of cancer cells. Upon DNA damage, cells stop proliferation at cell cycle checkpoints, which provides them time for DNA repair. Inhibiting the checkpoint allows entry to mitosis despite the presence of DNA damage and can lead to cell death. Importantly, as cancer cells exhibit increased levels of endogenous DNA damage due to an excessive replication stress,...
Paper Details
Title
Targeting the Checkpoint to Kill Cancer Cells
Published Date
Aug 18, 2015
Journal
Volume
5
Issue
3
Pages
1912 - 1937
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Notes
History