Fibrinogen as a therapeutic target for bleeding: a review of critical levels and replacement therapy.

Volume: 54, Issue: 5, Pages: 1389 - 1405
Published: May 1, 2014
Abstract
Fibrinogen plays a critical role in achieving and maintaining hemostasis and is fundamental to effective clot formation. There is increasing awareness of the important role of fibrinogen as a key target for the treatment and prevention of acquired bleeding. Fibrinogen is the first coagulation factor to fall to critically low levels (<1.0 g/L) during major hemorrhage (normal plasma fibrinogen levels range from 2.0 to 4.5 g/L), and current...
Paper Details
Title
Fibrinogen as a therapeutic target for bleeding: a review of critical levels and replacement therapy.
Published Date
May 1, 2014
Volume
54
Issue
5
Pages
1389 - 1405
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