Anaplastic Lymphoma Kinase as a Cancer Target in Pediatric Malignancies

Volume: 22, Issue: 3, Pages: 546 - 552
Published: Jan 31, 2016
Abstract
In this era of more rational therapies, substantial efforts are being made to identify optimal targets. The discovery of translocations involving the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase in a subset of non–small cell lung cancers has become a paradigm for precision medicine. Notably, ALK was initially discovered as the fusion gene in anaplastic large cell non-Hodgkin lymphoma, a disease predominantly of childhood. The...
Paper Details
Title
Anaplastic Lymphoma Kinase as a Cancer Target in Pediatric Malignancies
Published Date
Jan 31, 2016
Volume
22
Issue
3
Pages
546 - 552
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