Autophagy and antigen processing : strategies to enhance T cell recognition of cancer cells
Published: Jul 1, 2014
Abstract
Recent studies have suggested an increasingly important and therapeutically relevant role for CD4+ T cells as direct effectors in immunotherapy. It has also become clear that antigens can access the MHC-II pathway via non-classical endogenous routes such as autophagy. The aims of this project were to investigate endogenous MHC-II processing of tumour antigens and explore methods that, by enhancing such processing, could increase T cell...
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