Delta-lactoferrin, an intracellular lactoferrin isoform that acts as a transcription factor¹This article is part of a Special Issue entitled Lactoferrin and has undergone the Journal's usual peer review process.

Delta-lactoferrin (ΔLf) is a transcription factor of which the expression is downregulated in cancer. It is a healthy tissue marker and a high expression level of its transcripts was correlated with a good prognosis in breast cancer. ΔLf results from alternative promoter usage of the hLf gene leading to the production of 2 isoforms with alternative N-termini: lactoferrin, which is secreted, and ΔLf, its nucleocytoplasmic counterpart. ΔLf...