The Mutation G20210→A in the Prothrombin Gene Is a Strong Risk Factor for Pulmonary Embolism

It has been reported recently by Poort et al. (1) that the mutation G20210→A in the 3′-untranslated region of the prothrombin gene is associated with increased plasma prothrombin concentrations and venous thrombosis. The G20210→A mutation was found in 18% of 28 selected patients with a personal and family history of venous thrombosis as well as in 6.2% of 471 unselected patients with a first episode of deep venous thrombosis. On the other hand,...