Reduction of nicotinamide adenine dinucleotide levels by ultimate carcinogens in human lymphocytes.
Abstract
The effect of several classes of DNA-damaging chemicals and closely related compounds on cellular nicotinamide adenine dinucleotide (NAD) levels was studied in freshly isolated peripheral human lymphocytes. Of the 21 compounds examined, 7 were direct DNA-damaging agents and 14 were non-DNA-damaging compounds or required metabolic activation to casue DNA damage. Rapid lowering of cellular NAD levels was caused by each of the direct DNA-damaging...
Paper Details
Title
Reduction of nicotinamide adenine dinucleotide levels by ultimate carcinogens in human lymphocytes.
Published Date
Jun 1, 1980
Journal
Volume
40
Issue
6
Pages
1803 - 7
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Notes
History