Tetrazolium-based assays for cellular viability: a critical examination of selected parameters affecting formazan production.
Abstract
The hydrogen acceptor 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide (MTT) is commonly utilized to estimate cellular viability in drug screening protocols. The present investigation was prompted, in part, by observations that reduction of MTT to its colored reaction product, MTT formazan, varied between cell lines and with culture age. A correlation was established between the D-glucose concentration of the culture medium at the...
Paper Details
Title
Tetrazolium-based assays for cellular viability: a critical examination of selected parameters affecting formazan production.
Published Date
May 15, 1991
Journal
Volume
51
Issue
10
Pages
2515 - 20
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History