A dietary polyactylene, Gymnasterkoreayne B, induces both intrinsic and extrinsic pathway of apoptosis through the signaling molecules revealed by secretome profiling (LB183)

Gymnasterkoreayne B (GKB) is a natural polyacetylene isolated from Gymnaster koraiensis . The antiproliferative activity of GKB has been reported in various human cancer cells but its mechanism is still unknown. Our objectivity of the study was to investigate the mechanism of the antiproliferative activity of GKB in HCT116 cancer cell and to search any possible candidates that may involve in the cell death signaling. In this study, we confirmed...