The role of Notch and gamma-secretase inhibition in an ovarian cancer model.
Abstract
The Notch pathway is dysregulated in ovarian cancer. We sought to examine the role of Notch and gamma-secretase (GS) inhibition in ovarian cancer.Established ovarian cancer cell lines were used. Quantitative polymerase chain reaction (qPCR) was used to determine the relative expression of Notch receptor and ligands. Effects of GS inhibition on proliferation, colony formation, and downstream effectors were examined via methylthiazole tetrazolium...
Paper Details
Title
The role of Notch and gamma-secretase inhibition in an ovarian cancer model.
Published Date
Mar 1, 2013
Journal
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