ZEB1: At the crossroads of epithelial-mesenchymal transition, metastasis and therapy resistance
Abstract
Zinc finger E-box binding homeobox 1 (ZEB1) is a transcription factor that promotes tumor invasion and metastasis by inducing epithelial-mesenchymal transition (EMT) in carcinoma cells. EMT not only plays an important role in embryonic development and malignant progression, but is also implicated in cancer therapy resistance. It has been hypothesized that carcinoma cells that have undergone EMT acquire cancer stem cell properties including...
Paper Details
Title
ZEB1: At the crossroads of epithelial-mesenchymal transition, metastasis and therapy resistance
Published Date
Feb 16, 2015
Journal
Volume
14
Issue
4
Pages
481 - 487
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