Anti‐Inflammatory Activities of Melatonin Derivatives in Lipopolysaccharide‐Stimulated RAW 264.7 Cells and Antinociceptive Effects in Mice

Preclinical Research This study describes the anti‐inflammatory activities of two semisynthesized melatonin ( MT ) derivatives, benzoyl‐melatonin ( BMT ) and acetyl‐melatonin ( AMT ), on the production of pro‐inflammatory mediators in lipopolysaccharide ( LPS )‐stimulated macrophage cells ( RAW 264.7) and their antinociceptive effects in mice. The MT derivatives inhibited production of nitric oxide NO and prostaglandin E 2 in LPS ‐stimulated RAW...