Activation of rapid oestrogen signalling in aggressive human breast cancers
Abstract
Oestrogen receptors can mediate rapid activation of cytoplasmic signalling cascades by recruiting Src and PI3K. However, the involvement of this pathway in breast cancer remains poorly defined. We have previously shown that methylation of ERα is required for the formation of the ERα/Src/PI3K complex and that ERα is hypermethylated in a subset of breast cancers. Here, we used Proximity Ligation Assay to demonstrate that this complex is present in...
Paper Details
Title
Activation of rapid oestrogen signalling in aggressive human breast cancers
Published Date
Oct 15, 2012
Journal
Volume
4
Issue
11
Pages
1200 - 1213
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