Distinct emt programs control normal mammary stem cells and tumour-initiating cells

Nature64.80
Volume: 525, Issue: 7568, Pages: 256 - 260
Published: Sep 10, 2015
Abstract
Tumour-initiating cells (TICs) are responsible for metastatic dissemination and clinical relapse in a variety of cancers. Analogies between TICs and normal tissue stem cells have led to the proposal that activation of the normal stem-cell program within a tissue serves as the major mechanism for generating TICs. Supporting this notion, we and others previously established that the Slug epithelial-to-mesenchymal transition-inducing transcription...
Paper Details
Title
Distinct emt programs control normal mammary stem cells and tumour-initiating cells
Published Date
Sep 10, 2015
Journal
Volume
525
Issue
7568
Pages
256 - 260
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