Click synthesis of a polyamidoamine dendrimer-based camptothecin prodrug
Abstract
In the present work we report on the click synthesis of a new camptothecin (CPT) prodrug based on anionic polyamidoamine (PAMAM) dendrimer intended for cancer therapy. We applied 'click' chemistry to improve polymer-drug coupling reaction efficiency. Specifically, CPT was functionalized with a spacer, 1-azido-3,6,9,12,15-pentaoxaoctadecan-18-oic acid (APO), via EDC/DMAP coupling reaction. In parallel, propargylamine (PPA) and...
Paper Details
Title
Click synthesis of a polyamidoamine dendrimer-based camptothecin prodrug
Published Date
Jan 1, 2015
Journal
Volume
5
Issue
72
Pages
58600 - 58608
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