GADD153/CHOP, a DNA damage-inducible protein, reduced CAAT/enhancer binding protein activities and increased apoptosis in 32D c13 myeloid cells.

GADD153/CHOP is a DNA damage-inducible, nuclear leucine zipper protein that is capable of producing a G1-S arrest in fibroblastic cells and of dimerizing with and inhibiting CAAT/enhancer binding protein (C/EBP) activities. CHOP was induced in 32D cl3 myeloid cells exposed to methylmethane sulfonate (MMS), a DNA alkylating agent. The degree of induction was dependent upon the dose of MMS to which the cells were exposed. CHOP was not expressed,...