Effects of Aerosolized Adenosine 5′-Triphosphate in Smokers and Patients With COPD

Chest9.60
Volume: 148, Issue: 2, Pages: 430 - 435
Published: Aug 1, 2015
Abstract
Extracellular adenosine 5'-triphosphate (ATP) stimulates vagal C and Aδ fibers in the lung, resulting in pronounced bronchoconstriction and cough mediated by P2X2/3 receptors located on vagal sensory nerve terminals. We investigated the effects of nebulized ATP on cough and symptoms in control subjects, healthy smokers, and patients with COPD and compared these responses to the effects of inhaled adenosine, the metabolite of ATP.We studied the...
Paper Details
Title
Effects of Aerosolized Adenosine 5′-Triphosphate in Smokers and Patients With COPD
Published Date
Aug 1, 2015
Journal
Volume
148
Issue
2
Pages
430 - 435
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