IκB kinase all zipped up

NF-κB is a transcription factor that has a pivotal place in several pathways by whichsignals are transmitted from the cell membrane to the nucleus. Among other reactions, it is animportant mediator of the inflammatory response. This factor is inhibited by being in acomplex, in the cytoplasm, with a molecule known as IκB, and is activated and goesabout its business in the nucleus when IkB is phosphorylated and then degraded. But what doesthe...