Curcumin raises lipid content by Wnt pathway in hepatic stellate cell

Activation of hepatic stellate cells (HSCs) is a pivotal event in liver fibrosis, which is characterized by dramatic disappearance of lipid droplets. However, the underlying molecular mechanisms are largely unknown. We aimed to explore the role of Wnt/β-catenin pathway in HSC lipogenesis and to examine the effects of curcumin in this molecular context.Primary rat HSCs were cultured in vitro for experiments. The Wnt activator WAY-262611 and...