A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis

Leukotriene B4(LTB4)1 is a potent chemoattractant that is primarily involved in inflammation, immune responses and host defence against infection2. LTB4 activates inflammatory cells by binding to its cell-surface receptor (BLTR)3. LTB4 can also bind and activate the intranuclear transcription factor PPARα, resulting in the activation of genes that terminate inflammatory processes4. Here we report the cloning of the complementary DNA encoding a...