PML–RARa modulates the vascular signature of extracellular vesicles released by acute promyelocytic leukemia cells
Abstract
Oncogenic transformation is believed to impact the vascular phenotype and microenvironment in cancer, at least in part, through mechanisms involving extracellular vesicles (EVs). We explored these questions in the context of acute promyelocytic leukemia cells (NB4) expressing oncogenic fusion protein, PML–RARa and exquisitely sensitive to its clinically used antagonist, the all-trans retinoic acid (ATRA). We report that NB4 cells produce...
Paper Details
Title
PML–RARa modulates the vascular signature of extracellular vesicles released by acute promyelocytic leukemia cells
Published Date
Sep 15, 2015
Journal
Volume
19
Issue
1
Pages
25 - 38
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