Phosphoramide and Oxazaphosphorine Mustards

Pages: 23 - 79
Published: Jan 14, 1997
Abstract
Phosphoramide mustards and their metabolic precursors, the oxazaphosphorine mustards, belong to the general class of alkylating agents. Some related compounds, the aryl- and alkyl-bis(2-chloroethyl)amines, were covered in the previous chapter. Two oxazaphosphorines, cyclophosphamide and ifosfamide (Fig. 1), are the only phosphorylated mustard compounds ordinarily prescribed for cancer treatment today (1). The developmental work that led to their...
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Title
Phosphoramide and Oxazaphosphorine Mustards
Published Date
Jan 14, 1997
Journal
Pages
23 - 79
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