Tumor Cell-selective Cytotoxicity of Matrix Metalloproteinase-activated Anthrax Toxin

Volume: 60, Issue: 21, Pages: 6061 - 6067
Published: Nov 1, 2000
Abstract
Matrix metalloproteinases (MMPs) are overexpressed in a variety of tumor tissues and cell lines, and their expression is highly correlated to tumor invasion and metastasis. To exploit these characteristics in the design of tumor cell-selective cytotoxins, we constructed two mutated anthrax toxin protective antigen (PA) proteins in which the furin protease cleavage site is replaced by sequences selectively cleaved by MMPs. These MMP-targeted PA...
Paper Details
Title
Tumor Cell-selective Cytotoxicity of Matrix Metalloproteinase-activated Anthrax Toxin
Published Date
Nov 1, 2000
Volume
60
Issue
21
Pages
6061 - 6067
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