Tumor Cell-selective Cytotoxicity of Matrix Metalloproteinase-activated Anthrax Toxin
Abstract
Matrix metalloproteinases (MMPs) are overexpressed in a variety of tumor tissues and cell lines, and their expression is highly correlated to tumor invasion and metastasis. To exploit these characteristics in the design of tumor cell-selective cytotoxins, we constructed two mutated anthrax toxin protective antigen (PA) proteins in which the furin protease cleavage site is replaced by sequences selectively cleaved by MMPs. These MMP-targeted PA...
Paper Details
Title
Tumor Cell-selective Cytotoxicity of Matrix Metalloproteinase-activated Anthrax Toxin
Published Date
Nov 1, 2000
Journal
Volume
60
Issue
21
Pages
6061 - 6067
Citation AnalysisPro
You’ll need to upgrade your plan to Pro
Looking to understand the true influence of a researcher’s work across journals & affiliations?
- Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
- Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.
Notes
History