Epigenetic silencing of the non-coding RNA nc886 provokes oncogenes during human esophageal tumorigenesis
Abstract
nc886 (= vtRNA2-1 or pre-miR-886) is a recently discovered noncoding RNA that is a cellular PKR (Protein Kinase RNA-activated) ligand and repressor. nc886 has been suggested to be a tumor suppressor, solely based on its expression pattern and genomic locus. In this report, we have provided sufficient evidence that nc886 is a putative tumor suppressor in esophageal squamous cell carcinoma (ESCC). In 84 paired specimens from ESCC patients, nc886...
Paper Details
Title
Epigenetic silencing of the non-coding RNA nc886 provokes oncogenes during human esophageal tumorigenesis
Published Date
Apr 27, 2014
Journal
Volume
5
Issue
11
Pages
3472 - 3481
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