Involvement of atypical transcription factor E2F8 in the polyploidization during mouse and human decidualization
Abstract
Polyploid decidual cells are specifically differentiated cells during mouse uterine decidualization. However, little is known about the regulatory mechanism and physiological significance of polyploidization in pregnancy. Here we report a novel role of E2F8 in the polyploidization of decidual cells in mice. E2F8 is highly expressed in decidual cells and regulated by progesterone through HB-EGF/EGFR/ERK/STAT3 signaling pathway. E2F8...
Paper Details
Title
Involvement of atypical transcription factor E2F8 in the polyploidization during mouse and human decidualization
Published Date
Jun 17, 2015
Journal
Volume
14
Issue
12
Pages
1842 - 1858
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