Antiplatelet Activity of Clopidogrel was not Reduced by Long-termCoadministration of Atorvastatin Compared with Coadministration ofFluvastatin

Background : Recently there has been concern about the antiplatelet effect of clopidogrel which could be attenuated by atorvastatin due to shared enzyme in metabolism. However, recent reports showed concomitant short-term use of statins does not significantly inhibit antiplatelet activity of clopidogrel. We analyzed how two statins metabolized by different hepatic enzymatic pathway together with long-term use of clopidogrel affect platelet...