Inhibition of endoplasmic reticulum stress attenuates aorta coarctation induced hypertension and kidney injury in diabetic Goto Kakizaki rats (LB724)

Hypertension (HT) is common in diabetes and substantially increases the risk for diabetic nephropathy. To investigate the mechanisms by which HT and diabetes interact to promote nephropathy, 6 month‐old male Goto‐Kakizaki (GK) rats, a model of spontaneous type 2 diabetes, were used in this study. HT was induced by aorta coarctation (AC) between the renal arteries to produce HT plus diabetes in the right kidney (above AC) and normal blood...