PPARδ and PGE2 signaling pathways communicate and connect inflammation to colorectal cancer
Abstract
The nuclear hormone receptor peroxisome proliferator-activated receptor δ (PPARδ) is a ligand-dependent transcription factor that is involved in fatty acid metabolism, obesity, wound healing, inflammation, and cancer. Despite decades of research, the role of PPARδ in inflammation and colorectal cancer remains unclear and somewhat controversial. Our recent work presented the first genetic evidence demonstrating that PPARδ is required for chronic...
Paper Details
Title
PPARδ and PGE2 signaling pathways communicate and connect inflammation to colorectal cancer
Published Date
Oct 23, 2014
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