The role of protein synthesis in saturated fatty acid‐induced ER stress in H4IIE liver cells (1116.7)

Elevated fatty acids play a role in non‐alcoholic fatty liver disease (NAFLD). Disruption of endoplasmic reticulum (ER) homeostasis, or ER stress, is a characteristic feature of NAFLD. Elevated fatty acids, in particular saturated fatty acids, induce ER stress in numerous cell types including hepatocytes. However, the specific mechanisms that link fatty acids to ER stress in the liver are poorly understood. ER stress is the result of an...