Degradation of MSCRAMM target macromolecules in VLU slough byLucilia sericatachymotrypsin 1 (ISP) persists in the presence of tissue gelatinase activity

Venous leg ulcer slough is unpleasant to the patient and difficult to manage clinically. It harbours infection, also preventing wound management materials and dressings from supporting the underlying viable tissues. In other words, slough has significant nuisance value in the tissue viability clinic. In this study, we have sought to increase our knowledge of slough by building upon a previous but limited analysis of this necrotic tissue. In...