Dietary vitamin B9 is a survival factor of intestinal regulatory T cells (166.2)

It is well known that dietary factors regulate versatile immunological functions, but the detail molecular and cellular mechanisms remain to be investigated. Here we show that vitamin B9 is a survival factor of regulatory T (Treg) cells in the intestine when it is supplied from diet. In vitamin B9-null condition, naïve T cells could differentiate into Treg cells, but differentiated Treg cells failed to survive. This effect was dose-dependent...