Abstract 16784: Doxycycline Modulates Cardiomyocyte Remodeling in Light Chain-Induced Cardiac Amyloidosis

Cardiac amyloidosis due to clonal immunoglobulin light chain (AL) is a potentially fatal disease. The mechanism(s) of cardiac dysfunction and myocardial damage caused by amyloid fibrils deposition represents the least understood aspect of amyloid pathology. Once diagnosed with heart failure (HF), the median survival of AL cardiac amyloidosis (ALCMP) patients is <6months if left untreated. However, only a minority of ALCMP patients are...