MUC4 overexpression is associated with invasion and metastasis of pancreatic adenocarcinoma cells

3522 null null MUC4 is a large, heavily glycosylated trans-membrane mucin, which is overexpressed in various cancers. Since MUC4 is overexpressed in pancreatic cancer and not expressed in the normal pancreas, it is critical to explore its role in this malignancy. MUC4 is synthesized as a single polypeptide chain, which may be cleaved to generate two subunits: a larger size mucin type-subunit, MUC4α (secreted) and a growth factor...