Activation of PAR2receptors sensitizes primary afferents and causes leukocyte rolling and adherence in the rat knee joint

Volume: 167, Issue: 8, Pages: 1665 - 1678
Published: Nov 29, 2012
Abstract
The PAR(2) receptors are involved in chronic arthritis by mechanisms that are as yet unclear. Here, we examined PAR(2) activation in the rat knee joint.PAR(2) in rat knee joint dorsal root ganglia (DRG) cells at L3-L5, retrogradely labelled with Fluoro-gold (FG) were demonstrated immunohistochemically. Electrophysiological recordings from knee joint nerve fibres in urethane anaesthetized Wistar rats assessed the effects of stimulating joint...
Paper Details
Title
Activation of PAR2receptors sensitizes primary afferents and causes leukocyte rolling and adherence in the rat knee joint
Published Date
Nov 29, 2012
Volume
167
Issue
8
Pages
1665 - 1678
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