A new type of hemophore-dependent heme acquisition system of Serratia marcescens reconstituted in Escherichia coli
Abstract
The utilization by Serratia marcescens of heme bound to hemoglobin requires HasA, an extracellular heme-binding protein. This unique heme acquisition system was studied in an Escherichia coli hemA mutant that was a heme auxotroph. We identified a 92-kDa iron-regulated S. marcescens outer membrane protein, HasR, which alone enabled the E. coli hemA mutant to grow on heme or hemoglobin as a porphyrin source. The concomitant secretion of HasA by...
Paper Details
Title
A new type of hemophore-dependent heme acquisition system of Serratia marcescens reconstituted in Escherichia coli
Published Date
Jun 1, 1997
Journal
Volume
179
Issue
11
Pages
3572 - 3579
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